I Reject My Humanity, JoJo! is an iconic quote and scene from the first part of the anime and manga series JoJo's Bizarre Adventure: Phantom Blood. In this scene, the antagonist Dio Brando announces his intention to become a vampire by using a cursed stone mask, famously declaring his renunciation of his human status to his foster brother, Jonathan Joestar. The meme gained massive popularity for its dramatic flair and over-the-top energy, often used to signify a person abandoning their normal behavior, diet, or social expectations in favor of something radical or obsessive. It serves as the ultimate declaration of 'going all in' on a new, often questionable, lifestyle choice.