The 'How to Pick Up X' meme, also known as 'How to Handle X,' originated from a series of instructional diagrams detailing the proper way to hold various animals, most notably a duck. The format became a viral sensation as internet users began substituting the ducks with various fictional characters, celebrities, or abstract concepts while maintaining the iconic advice to 'support the bottom.' It is widely used to humorously illustrate how to care for or 'handle' specific personality types or fandom favorites, relying on the contrast between the clinical, instructional art style and the absurdity of the subject being picked up.