The 'Homer Simpson in a Lesbian Bar' meme originates from the Season 6 episode of The Simpsons titled 'Fear of Flying,' which first aired in 1994. In the scene, Homer is banned from Moe’s Tavern and searches for a new place to drink, accidentally wandering into a lesbian bar called 'She-She’s.' The meme captures the exact moment Homer realizes something is 'off' but can't quite put his finger on it, leading to the classic line, 'Wait a minute... this lesbian bar doesn't have a fire exit!' It is widely used on the internet to represent being completely oblivious in a situation where everyone else is on the same page, or simply feeling like an outsider in a specific social environment.