This meme features YouTuber JonTron (Jon Jafari) in a scene from his 2017 'Flex Tape II: The Extreme' video. In the clip, Jon responds to a commercial where a woman gets covered in glue with the exaggerated line, 'Holy shit, you fucking killed her, dude!' The internet quickly adopted the screencap and caption as the ultimate reaction to 'savage' social media roasts or intense verbal takedowns. It is widely recognized as the gold standard for responding to posts on platforms like Reddit's r/MurderedByWords, signaling that a comeback was so effective it essentially 'annihilated' the original poster's argument.