The Hohoho meme features Ben, the retired chemistry professor dog from the 'Talking Ben' mobile app. While the app originally launched in 2011, it regained massive viral status in late 2021 and 2022 through streamers like IShowSpeed. The meme centers on Ben's specific phone dialogue, particularly his iconic 'Ho ho ho' laugh combined with 'Yes', 'No', and 'Ugh' responses. It is frequently used in 'Calling Talking Ben' video edits where users ask ridiculous or controversial questions and Ben provides nonsensical, blunt, or perfectly timed answers. This format has become a staple of internet culture, representing the peak of absurdist mobile gaming humor.