The 'Here we go again' meme features Carl 'CJ' Johnson from the 2004 video game Grand Theft Auto: San Andreas. The line is spoken at the very beginning of the game when CJ returns to Los Santos and is confronted by corrupt police officers. While the game is decades old, the scene exploded into viral status as a reaction image and video starting around 2019. It is universally used to describe a sense of dread or resignation when a frustrating or familiar situation repeats itself, ranging from difficult gaming levels to relatable everyday life inconveniences.