The 'Hamburger Helper Anatomy' meme centers on the iconic mascot 'Lefty,' the four-fingered white glove used to market Hamburger Helper products. The trend began when artists and internet users started speculating on the internal biology of a living glove, leading to a series of increasingly disturbing and 'cursed' anatomical diagrams. These range from a skeletal hand with a thumb-head to a four-legged mammalian creature curled inside. The meme gained massive traction on Twitter and Tumblr as a form of surreal humor, poking fun at the logistics of corporate mascots. It is typically used to contrast a friendly exterior with a hidden, horrifying, or nonsensical reality.