The 'Garfield Dog Semen' comic strip refers to a real panel published on May 30, 1990, featuring Jon Arbuckle mistakenly drinking a 'protein supplement' meant for a pregnant dog. Decades later, the internet rediscovered the strip and reinterpreted the joke through a much darker, adult lens, leading it to become a viral sensation. While creator Jim Davis clarified the intended joke was simply about Jon drinking animal medicine, the meme persists as one of the most infamous and accidentally inappropriate moments in comic strip history. It is frequently used to represent characters realizing they have consumed something horrific or to highlight the absurdity of 90s newspaper humor.