The Finding Nemo meme series primarily draws from the 2003 Pixar classic, featuring iconic characters like Marlin, Dory, and Bruce the shark. The most popular variation involves Bruce's shark support group and their mantra, 'Fish are friends, not food,' often used to mock situations where someone tries to act against their natural, more aggressive instincts. Other popular formats include Marlin's frantic search or Dory's 'Just keep swimming' advice. These memes resonate due to the film's nostalgic value and the relatable, often chaotic energy of the characters, making them staples for expressing persistence, friendship, or irony across social media platforms.