The 'Nyeeeeees' meme originates from the chaotic YouTube series 'The Filthy Frank Show', which peaked in cultural relevance around 2014 and 2015. In this specific recurring bit, the character Filthy Frank, portrayed by the multi-talented creator George 'Joji' Miller, contorts his face and leans into the camera to deliver an exaggerated, high-pitched vocalization. This auditory explosion of 'Nyeeeeees!' became a signature catchphrase for the channel's absurdist and often transgressive humor. In the meme world, this clip is used to represent a manic sense of agreement or the celebration of a truly terrible idea. It captures the energy of someone leaning into their own degenerate behavior or finding unhinged joy in a cursed situation. Common caption examples include 'Me agreeing to go out when I have $4 in my bank account,' 'When your friend suggests a 3am McDonald's run,' or 'My last two brain cells when I finally understand a math problem.'