The 'Guiltyyyyy' meme originates from the hit animated series Family Guy, specifically featuring the protagonist Peter Griffin, voiced by Seth MacFarlane. In this iconic scene from the early seasons of the show (circa 2000), Peter points his finger and shouts the word 'Guilty!' with increasing intensity and dramatic flair. The clip has become a staple of internet culture due to Peter's exaggerated facial expressions and the sheer comedic weight of his accusation. It is commonly used as a reaction video to call out someone who has been caught red-handed in a lie, a social faux pas, or a relatable 'crime' like eating the last slice of pizza. The meme perfectly captures the feeling of mock judgment and the satisfaction of exposing a friend's secret habits. Example captions include: 'Me when my friend says they're broke but just posted a five-course meal on their story,' 'The jury when they see my browser history,' and 'When you catch your sibling wearing your favorite hoodie.'