This meme features the character D.W. Read from the popular children's animated series Arthur. The image originates from the season 3 episode 'Buster's Back,' where D.W. is told she can't enter a room. While the specific quote 'That sign can't stop me because I can't read' isn't the exact dialogue from the scene, the internet pairing of her defiant stance with that caption perfectly captured her bratty and determined personality. It gained massive popularity on Tumblr and Twitter in the early 2010s as a way to illustrate people ignoring clear warnings, rules, or logic with willful ignorance.