The 'What Do You Mean By That?' meme originated from a viral video featuring comedian Druski during one of his 'CouldBeRecords' sketches or Instagram Live sessions. In the clip, Druski reacts with immediate suspicion and a hilarious facial expression to a statement that sounds potentially 'sus' or unintentionally suggestive. It quickly evolved into a universal reaction image used to interrogate double entendres, questionable motives, or anything that feels slightly off-kilter. The meme's power lies in Druski's perfect comedic timing and the relatability of needing immediate clarification when a conversation takes an unexpected turn.