The #DroptheB meme originates from the 2024 film Despicable Me 4, specifically featuring the super-powered 'Mega Minion' named Mel. In the viral scene, Mel is instructed to fire his massive eye-laser, an action translated by fans into the catchphrase 'Drop the B.' The meme exploded on TikTok and Instagram, where users sync the laser's firing sequence with heavy bass drops or use it to represent a sudden, explosive reaction to a situation. It captures the perfect blend of the Minions' classic chaotic energy and a modern cinematic 'superhero' aesthetic, making it a staple for high-energy video edits and social media reactions.