Detroit: Become Human memes primarily stem from the 2018 Quantic Dream video game, specifically focusing on the android protagonist Connor. The most famous variations include the 'Stress Level 99%' HUD overlay and the aggressive '28 Stab Wounds!' interrogation scene. These memes are widely used to humorously depict high-anxiety situations, social awkwardness, or moments of intense realization. The aesthetic of the game's user interface, featuring clean blue lines and futuristic HUD elements, is often applied to real-world scenarios where an individual appears to be reaching their breaking point or acting in a particularly robotic manner.