The 'Destiel Is Canon' meme refers to the pivotal moment in the long-running TV series Supernatural when the angel Castiel confesses his love for Dean Winchester. After over a decade of fan shipping and speculation, the pairing became officially canon during the Season 15 episode 'Despair,' which aired on November 5, 2020. The internet reaction was unprecedented, with the confession trending alongside global news events, creating a unique cultural crossover. The meme typically uses screenshots from the emotional scene or reaction images that capture the shock, joy, and chaotic energy of the fandom finally seeing their favorite couple acknowledged on screen.