The 'Connect Four' meme is a popular image macro series that involves photoshopping the box art of the classic Milton Bradley board game. Originally released in 1974, the game's recognizable blue grid and yellow/red checkers became a target for internet humor as early as the late 2000s. Creators typically replace the title 'Connect Four' with a single word or phrase—often something negative, absurd, or relatable like 'Depression' or 'Alcoholism'—to subvert the wholesome family image of the original game. It is frequently used to mock specific cultural trends or life experiences by framing them as a game where the outcome is inevitably ironic or tragic.