The 'Changed' meme originates from the 2018 survival puzzle game developed by DragonSnow, which gained a massive following for its unique art style and 'transfur' mechanics. The story follows a human attempting to escape a facility filled with goo-like latex creatures that seek to transform them. Memes typically revolve around the character Puro, the game's difficult puzzles, or the shocking nature of the transformation sequences. It has evolved into a niche but powerful internet trope often used to reference the 'if you know, you know' aspect of the game's transformation themes and its surprisingly deep lore.