The Bubbles No Me Gusta meme is a cross-over classic that combines the innocent character Bubbles from The Powerpuff Girls with the iconic 'No Me Gusta' rage face or a similarly distorted expression of pure disdain. Often used to represent a visceral reaction to something unpleasant or annoying, this meme captures the hilarious contrast between Bubbles’ usually cheerful persona and a moment of extreme negativity. It gained traction in the early 2010s during the height of rage comic popularity and remains a go-to template for expressing disapproval or showing that something definitely does not 'sit right' with the viewer.