The 'Assad Must Go' meme, often referred to as the 'Assad Curse,' originates from the Syrian Civil War era when numerous world leaders called for the resignation of Bashar al-Assad. The meme highlights the irony that many of these leaders—including Barack Obama, David Cameron, and Theresa May—eventually left office or lost political power while Assad remained in his position. Typically formatted as a two-panel image, the top half shows a politician declaring 'Assad must go,' followed by a bottom half featuring a smiling Assad asking 'Who must go?' It has become a staple of internet irony and political satire, used to mock the perceived failure of foreign policy intervention or simply to highlight the survival of the Syrian leader against political odds.