The 'Are you two friends?' meme is taken from the Star Trek: Voyager episode 'Prophecy,' which first aired in 2001. The scene features Ensign Harry Kim asking Tuvok and Neelix about their relationship, resulting in Tuvok's iconic and immediate 'No' response. The humor lies in the stark contrast between Neelix's friendly smile and Tuvok's cold, Vulcan logic. It gained massive popularity online as a way to describe two things that are often seen together but share a completely one-sided or reluctant dynamic.