The 'Angry Dr. Mario' or 'Dr. Mario’s Origin Story' meme emerged in 2024 as part of a trend utilizing AI video generators like Luma Dream Machine to create cinematic, hyper-realistic, and often dark backstories for beloved video game characters. This specific template depicts the usually cheerful Mario in his medical persona, appearing stressed, exhausted, or vengeful within a gritty hospital setting. The meme typically parodies the absurdity of the game's mechanics—throwing multi-colored pills at sentient viruses—by framing it as a desperate, psychological response to a medical tragedy. It has become a staple for users wanting to express intense frustration, 'villain arc' moments, or the feeling of being overwhelmed in professional environments.