The Abuelo Simpson meme primarily stems from two legendary moments in The Simpsons featuring Abraham 'Abe' Simpson. One is the 'Old Man Yells at Cloud' newspaper headline from the episode 'The Old Man and the Key,' symbolizing misplaced frustration. The other, often called 'Abe Simpson Entering and Leaving,' comes from the episode 'Bart After Dark,' where Abe enters a room, sees his grandson Bart, and immediately turns 360 degrees to exit. These memes are globally used to express instant regret, awkward situations, or the confusion of the older generation in a digital world.